Q1 “Varicose veins run in families”
There was some excellent work by Prof CV Ruckley in Scotland over many years that mapped how varicose veins and venous disease did run in families. However, unlike genetic traits such as hair colour, eye colour or blood group which follow simple genetics, the inheritance or otherwise of varicose veins or “hidden varicose veins” (venous reflux disease or venous incompetence) is more complicated.
Therefore in certain families, a great many of the members will have varicose veins or “hidden varicose veins”, but not everyone will. Similarly, in other families, most people may not have the problem but one or two members will end up suffering from varicose veins or “hidden varicose veins”. Therefore the fact that varicose veins do run in families cannot be due to simple genetics.
Moreover, if there was a simple genetic cause of varicose veins then when somebody got varicose veins, it should affect all of their veins in both of their legs and all of their veins will have the same genetic make-up. Instead, we quite frequently see varicose veins only in one leg or in just one of the veins of the leg, with other veins in the same leg not being affected.
For these reasons, we can be sure that there is a familial link and that varicose veins to run in families, but it is not by simple genetics and cannot be predicted as to which individual will or will not get varicose veins or “hidden varicose veins“.
Q2 “Women get varicose veins more often than men”